Waeber B, Hayoz D, Evéquoz D, Brunner H R
Hypertension Division, University Hospital, Lausanne, Switzerland.
J Hypertens Suppl. 1992 Aug;10(6):S79-81.
These studies were undertaken in intact spontaneously hypertensive rats (SHR) to assess whether the elastic behavior of conduit arteries changes as a function of age.
We studied 16-week-old (n = 10) and 36-week-old (n = 10) SHR under fluothane anesthesia. Diameter-, compliance-, and distensibility-pressure curves were established non-invasively for the carotid artery by means of a high-precision ultrasonic echo-tracking device. Intra-arterial pressure was monitored simultaneously in the contralateral carotid artery.
Mean blood pressure was 197 +/- 6 and 185 +/- 3 mmHg (mean +/- SEM) in the younger and older SHR, respectively. No significant difference was observed between the two groups of rats in the diameter-, compliance- and distensibility-pressure curves.
These results suggest that the elastic behavior of elastic arteries is not necessarily altered with aging in rats with genetic hypertension.
在完整的自发性高血压大鼠（SHR）中进行这些研究，以评估传导动脉的弹性行为是否随年龄变化。
我们在氟烷麻醉下研究了16周龄（n = 10）和36周龄（n = 10）的SHR。通过高精度超声回声跟踪装置对颈动脉进行非侵入性地建立直径-顺应性-扩张性压力曲线。同时在对侧颈动脉监测动脉内压力。
较年轻和较年长的SHR的平均血压分别为197±6和185±3 mmHg（平均值±标准误）。两组大鼠在直径-顺应性-扩张性压力曲线上未观察到显著差异。
这些结果表明，遗传性高血压大鼠的弹性动脉弹性行为不一定随年龄而改变。
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