劳氏肉瘤病毒的转化：DNA合成的必要条件。

TRANSFORMATION OF ROUS SARCOMA VIRUS: A REQUIREMENT OF DNA SYNTHESIS.

作者信息

BADER J P

出版信息

Science. 1965 Aug 13;149(3685):757-8. doi: 10.1126/science.149.3685.757.

DOI:10.1126/science.149.3685.757

Abstract

Transient inhibition of DNA synthesis immediately after infection of cells with Rous sarcoma virus prevents subsequent morphological transformationof the cells. Inhibition of DNA synthesis for an identical period before infection, or later in the course of infection, has only slight effect on transformation. Thus DNA synthesis is a specific requirement in the transformation of cells by Rous sarcoma virus.

摘要

用劳氏肉瘤病毒感染细胞后立即短暂抑制DNA合成可阻止细胞随后的形态转化。在感染前相同时间段或感染过程后期抑制DNA合成对转化只有轻微影响。因此，DNA合成是劳氏肉瘤病毒转化细胞的一个特定要求。