一项关于镁离子与核苷二磷酸相互作用的31P核磁共振研究。
A 31P-NMR study of the interaction of Mg2+ ions with nucleoside diphosphates.
作者信息
Tran-Dinh S, Neumann J M
出版信息
Nucleic Acids Res. 1977 Feb;4(2):397-403. doi: 10.1093/nar/4.2.397.
Abstract
The interaction of Mg2+ with nucleoside disphosphates : ADP, GDP, CDP and UDP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution. The results show that these four nucleotides behave similarly, the Mg2+ ion binds to the alpha but not to the beta phosphate moiety. The strength of the interaction of Mg2+ ions with nucleoside diphosphates is weaker than with nucleoside triphosphates. The association of Mg2+ on the phosphate chain is stronger in a neutral than in an acid medium.
摘要
通过磷磁共振光谱法在水溶液中研究了Mg2+与二磷酸核苷：ADP、GDP、CDP和UDP的相互作用。结果表明，这四种核苷酸表现相似，Mg2+离子与α-磷酸基团结合，而不与β-磷酸基团结合。Mg2+离子与二磷酸核苷的相互作用强度比与三磷酸核苷的弱。在中性介质中，Mg2+在磷酸链上的缔合比在酸性介质中更强。
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