Kravitz H M, Katz R, Kot E, Helmke N, Fawcett J
Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL.
J Rheumatol. 1992 Sep;19(9):1428-32.
Both fibromyalgia and depression may be related to disturbed serotonin metabolism, and an association between the 2 disorders has been postulated. We measured 3H-imipramine binding (IB), a biochemical indicator of serotonin uptake, pretreatment, in 10 nondepressed women with fibromyalgia, 14 subjects with major depression, and 10 volunteer controls. Our objective was to determine if IB in the 2 patient groups differed and in the same direction from the control values. Compared with depressed women, IB was significantly lower both in the women with fibromyalgia and in the men with depression. However, no women with fibromyalgia or men with depression had IB levels that were significantly different from control women and men. There was a trend for higher IB levels in depressed compared to control women.
纤维肌痛和抑郁症都可能与血清素代谢紊乱有关，并且已经假定这两种疾病之间存在关联。我们在10名无抑郁的纤维肌痛女性、14名重度抑郁症患者和10名志愿者对照中，测量了血清素摄取的生化指标——3H-丙咪嗪结合（IB），作为预处理。我们的目的是确定两组患者的IB是否与对照值不同且方向相同。与抑郁症女性相比，纤维肌痛女性和抑郁症男性的IB均显著降低。然而，没有纤维肌痛女性或抑郁症男性的IB水平与对照女性和男性有显著差异。与对照女性相比，抑郁症患者的IB水平有升高的趋势。
