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γδ T细胞对清除病毒感染细胞是否重要?

Are gamma delta T cells important for the elimination of virus-infected cells?

作者信息

Malkovsky M, Bartz S R, MacKenzie D, Radtke B E, Wallace M, Manning J, Pauza C D, Fisch P

机构信息

Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison 53706.

出版信息

J Med Primatol. 1992 Feb-May;21(2-3):113-8.

PMID:1433261
Abstract

Rhesus monkeys (Macaca mulatta) gamma delta T cells were identified using a monoclonal antibody. The relative representation of gamma delta T lymphocytes in the peripheral blood, lymph nodes, and spleen resembles that of Homo sapiens. The analysis of function and specificity revealed further significant similarities between the simian and human gamma delta T-cell systems. Since both human and monkey gamma delta T lymphocytes can effectively lyse cells infected with immunodeficiency viruses, it is possible that the primate gamma delta T-cell systems contribute to antiviral immunosurveillance.

摘要

使用单克隆抗体鉴定了恒河猴(猕猴)的γδ T细胞。外周血、淋巴结和脾脏中γδ T淋巴细胞的相对占比与人类相似。功能和特异性分析揭示了猿猴和人类γδ T细胞系统之间进一步的显著相似性。由于人类和猴的γδ T淋巴细胞都能有效裂解感染免疫缺陷病毒的细胞,灵长类动物的γδ T细胞系统有可能有助于抗病毒免疫监视。

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