Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Department of Infectious Diseases, Melbourne Sexual Health Centre, Alfred Health, Central Clinical School, Monash University, Clayton, VIC, Australia.
Front Cell Infect Microbiol. 2020 May 19;10:233. doi: 10.3389/fcimb.2020.00233. eCollection 2020.
Elimination of the latent HIV reservoir remains a major barrier to achieving an HIV cure. In this review, we discuss the cytolytic nature of human gamma delta T cells and highlight the emerging evidence that they can target and eliminate HIV-infected T cells. Based on observations from human clinical trials assessing gamma delta immunotherapy in oncology, we suggest key questions and research priorities for the study of these unique T cells in HIV cure research.
消除潜伏的 HIV 储存库仍然是实现 HIV 治愈的主要障碍。在这篇综述中，我们讨论了人类 γδ T 细胞的细胞溶解性质，并强调了它们可以靶向和消除 HIV 感染的 T 细胞的新证据。基于评估 γδ 免疫疗法在肿瘤学中的人类临床试验观察，我们提出了在 HIV 治愈研究中研究这些独特 T 细胞的关键问题和研究重点。
