Frankel D, Khanna J M, LeBlanc A E, Kalant H
Can J Physiol Pharmacol. 1977 Aug;55(4):954-7. doi: 10.1139/y77-128.
Rats developed cross-tolerance to the motor-impairing effects of ethanol after daily oral administration of pentobarbital. Chronic administration of p-chlorophenylalanine (p-CPA), in a dosage regimen previously demonstrated to maintain extensive brain serotonin (5-HT) depletion, slowed down cross-tolerance development. p-CPA did not appear to exert this effect by altering the disposition of ethanol, since blood ethanol levels measured 20 min after ethanol administration were not affected by p-CPA treatment. This study extends our previous findings with respect to the inhibitory effects of p-CPA on tolerance development to ethanol and pentobarbital, and suggests that 5-HT may play a role in cross-tolerance development between ethanol and pentobarbital.
在每日口服戊巴比妥后，大鼠对乙醇的运动损害作用产生了交叉耐受性。以先前证明可维持广泛脑血清素（5-HT）耗竭的给药方案长期给予对氯苯丙氨酸（p-CPA），减缓了交叉耐受性的发展。p-CPA似乎并非通过改变乙醇的处置来发挥这种作用，因为在给予乙醇20分钟后测得的血液乙醇水平不受p-CPA治疗的影响。本研究扩展了我们先前关于p-CPA对乙醇和戊巴比妥耐受性发展的抑制作用的发现，并表明5-HT可能在乙醇和戊巴比妥之间的交叉耐受性发展中起作用。
