Wu H, Zhu T B, Du J Y, Hong G X, Sun S Z, Xu X H
Department of Orthopedics, Xiehe Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1992;12(2):111-5. doi: 10.1007/BF02887792.
A new biomaterial, magnetic porous tricalcium phosphate ceramics (MPTCP), may be used for repairing defects in bones as a substitute for bone grafting. This study was designed to examine its biocompatibility and the systemic toxicity. The ceramic sections, approximately 15.3 mg, were implanted into both proximal femurs of 10 male and 10 female albino SW rats. An equal number of male and female animals served as sham-operated controls. Implantation of MPTCP ceramics in rat femurs had no deleterious effects on body weight, organ/body weight ratio, and on blood, liver and kidney functions. Plasma levels of inorganic phosphorus were significantly elevated in rats implanted with MPTCP ceramics. Alkaline phosphatase values in plasma in the experimental group were equal to those in the control group. Photomicrographs, radiographs and scanning electron photomicrographs of the rat femurs implanted with MPTCP ceramics demonstrated excellent bone association with implants and growth of some new bone into MPTCP ceramics. In conclusion, MPTCP ceramics are biocompatible and suitable for the reconstruction of bones.
一种新型生物材料——磁性多孔磷酸三钙陶瓷（MPTCP），可作为骨移植替代品用于修复骨缺损。本研究旨在检测其生物相容性和全身毒性。将约15.3毫克的陶瓷切片植入10只雄性和10只雌性白化病SW大鼠的双侧股骨近端。同等数量的雄性和雌性动物作为假手术对照组。在大鼠股骨中植入MPTCP陶瓷对体重、器官/体重比以及血液、肝脏和肾脏功能均无有害影响。植入MPTCP陶瓷的大鼠血浆无机磷水平显著升高。实验组血浆碱性磷酸酶值与对照组相等。植入MPTCP陶瓷的大鼠股骨的显微照片、X线照片和扫描电子显微照片显示，植入物与骨结合良好，且有一些新骨长入MPTCP陶瓷。总之，MPTCP陶瓷具有生物相容性，适用于骨重建。
