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人类接受匹配的无关供者骨髓移植后短暂植活情况下淋巴细胞的体内培养。

Education of lymphocytes in vivo following a transient take of a matched unrelated bone-marrow graft in man.

作者信息

Goldmann S F, Kristensen T, Grunnet N, Lohrmann H P, Heimpel H, Kissmeyer-Nielsen F

出版信息

Clin Exp Immunol. 1977 Aug;29(2):266-71.

Abstract

A patient suffering from aplastic anaemia was treated by bone-marrow transplantation from an ABO- and HLA-identical, MLC- and CML-negative, unrelated donor. MLC and CML became positive after transplantation indicating that a cellular immune response had developed against lymphocyte determinants not recognized prior to sensitization in vivo. Whether these determinants are governed by genes of the HLA region is unknown at present.

摘要

一名再生障碍性贫血患者接受了来自 ABO 和 HLA 匹配、MLC 和 CML 阴性的无关供体的骨髓移植。移植后 MLC 和 CML 呈阳性,表明针对体内致敏前未识别的淋巴细胞决定簇产生了细胞免疫反应。目前尚不清楚这些决定簇是否受 HLA 区域基因的控制。

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