Yunis E J, Amos D B
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031-5. doi: 10.1073/pnas.68.12.3031.
The concept that antigens of a major histocompatibility locus (HL-A), the mixed leukocyte reaction, and the rejection of a graft are expressions of the same genetic region has been generally accepted. WE HAVE PRESENTED EXPERIMENTS THAT CHALLENGE THE ABOVE CONCEPT AND SUGGEST THAT THE REJECTION TIME OF SKIN AND ORGAN TRANSPLANTS IS DEPENDENT ON IMMUNIZATION AGAINST THE PRODUCTS OF TWO, AND POSSIBLY THREE, SEPARATE, BUT CLOSELY LINKED, GENETIC SYSTEMS: HL-A, mixed leukocyte reaction (MLR-S), and hypersensitivity delayed reaction (HDR). The findings presented and discussed here suggest that the HL-A antigens are not the primary factors involved in the cell-mediated component of allotransplantation, and that these antigens and phenotypes of the mixed leukocyte reaction can only be used as a guide in predicting the survival of allografts that are obtained from unrelated donors.
主要组织相容性位点(HL - A)的抗原、混合淋巴细胞反应以及移植物排斥反应是同一基因区域的表现形式,这一概念已被普遍接受。我们进行了一些实验,对上述概念提出了挑战,并表明皮肤和器官移植的排斥时间取决于针对两个,可能还有三个独立但紧密连锁的基因系统的产物进行免疫:HL - A、混合淋巴细胞反应(MLR - S)和迟发型超敏反应(HDR)。此处呈现和讨论的研究结果表明,HL - A抗原并非同种异体移植细胞介导成分中的主要因素,并且这些抗原和混合淋巴细胞反应的表型仅可作为预测来自无关供体的同种异体移植物存活情况的指南。