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因使用氟他胺治疗前列腺癌继发的近乎致命的肝功能障碍。

Near fatal liver dysfunction secondary to administration of flutamide for prostate cancer.

作者信息

Dankoff J S

机构信息

Department of Urology, Northeastern Ohio Universities, College of Medicine, Akron.

出版信息

J Urol. 1992 Dec;148(6):1914. doi: 10.1016/s0022-5347(17)37071-4.

DOI:10.1016/s0022-5347(17)37071-4
PMID:1433640
Abstract

A 66-year-old man with metastatic prostate cancer was treated with bilateral orchiectomy and 750 mg. flutamide per day. Near fatal liver dysfunction developed 10 weeks later. Flutamide was discontinued and 8 weeks later liver enzymes had returned to normal.

摘要

一名66岁的转移性前列腺癌男性患者接受了双侧睾丸切除术，并每天服用750毫克氟他胺。10周后出现了近乎致命的肝功能障碍。停用氟他胺，8周后肝酶恢复正常。

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Near fatal liver dysfunction secondary to administration of flutamide for prostate cancer.因使用氟他胺治疗前列腺癌继发的近乎致命的肝功能障碍。
J Urol. 1992 Dec;148(6):1914. doi: 10.1016/s0022-5347(17)37071-4.
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引用本文的文献

1
[Toxic hepatitis and liver failure under therapy with flutamide].
Internist (Berl). 2004 Mar;45(3):333-40. doi: 10.1007/s00108-003-1114-2.
2
Antiandrogens in prostate cancer.前列腺癌中的抗雄激素药物
Invest New Drugs. 1999;17(3):271-84. doi: 10.1023/a:1006344807086.