Møller S, Iversen P, Franzmann M B
Department of Medicine B259, University of Copenhagen, Denmark.
J Hepatol. 1990 May;10(3):346-9. doi: 10.1016/0168-8278(90)90144-g.
Two cases of clinically manifest liver failure in patients with metastatic prostatic cancer treated with the non-steroidal antiandrogen flutamide combined with a luteinizing hormone-releasing hormone analogue are described. One patient developed severe hepatic insufficiency with jaundice, ascites and hepatic coma. The condition reversed after discontinuation of flutamide. The other patient only became jaundiced with a biochemical cholestatic pattern. Previous reports of hepatic adverse reactions only include elevated transaminase levels without clinical manifestations. The morphological lesions in the liver biopsy and the clinical condition may be due to a reversible interaction with metabolic processes in the hepatocytes.
本文描述了两例转移性前列腺癌患者在接受非甾体类抗雄激素药物氟他胺联合促黄体生成素释放激素类似物治疗后出现临床明显肝衰竭的病例。其中一名患者出现严重肝功能不全，伴有黄疸、腹水和肝昏迷。停用氟他胺后病情好转。另一名患者仅出现黄疸，伴有生化胆汁淤积模式。既往关于肝脏不良反应的报道仅包括转氨酶水平升高而无临床表现。肝活检中的形态学病变及临床情况可能是由于与肝细胞代谢过程的可逆性相互作用所致。
