Imaizumi M, Ojika T, Watanabe H, Sakakibara M, Nishimura M, Abe T
Department of Thoracic Surgery, School of Medicine, Nagoya University.
Jpn J Antibiot. 1992 Aug;45(8):1039-49.
Serum concentrations of cefminox (CMNX) and piperacillin (PIPC) and their transfer into pulmonary tissue during surgery were serially studied following 1-hour intravenous instillation of 1 g of CMNX or PIPC immediately before thoracotomy, and the following results were obtained. Maximum serum concentrations of CMNX and PIPC were observed 1 hour after the commencement of administration, and their levels gradually decreased thereafter. The mean peak level of CMNX was 72.21 micrograms/ml, and T 1/2 was 1.62 hours. The mean peak level of PIPC was 43.26 micrograms/ml, and T 1/2 was 1.54 hours. In the pulmonary tissue, mean concentrations of CMNX in the normal pulmonary (alveolar) tissue were 28.80, 26.50 and 17.80 micrograms/g at 2.5, 3 and 4 hours, respectively, after the commencement of administration, and the corresponding levels for bronchiolar tissue were 19.6, 18.40 and 20.53 micrograms/g, respectively. The mean concentrations of PIPC in the normal pulmonary (alveolar) tissue were 18.97, 7.34 and 5.0 micrograms/g at 2, 3 and 4 hours, respectively, after the commencement of administration, and the corresponding levels for bronchiolar tissue were 7.2, 9.20 and less than 0.2 micrograms/g, respectively. PIPC also showed favorable transfer into the hilar lymph node tissue and obstructive pneumonitic lesions. The transfer of both drugs into pulmonary tissue suggests that both drugs are useful for the treatment of respiratory infectious diseases and the prevention of postoperative infections.
在开胸手术前立即静脉滴注1克头孢米诺（CMNX）或哌拉西林（PIPC）1小时后，连续研究了血清中头孢米诺（CMNX）和哌拉西林（PIPC）的浓度及其在手术过程中向肺组织的转移情况，结果如下。给药开始后1小时观察到CMNX和PIPC的血清最高浓度，此后其水平逐渐下降。CMNX的平均峰值水平为72.21微克/毫升，半衰期为1.62小时。PIPC的平均峰值水平为43.26微克/毫升，半衰期为1.54小时。在肺组织中，给药开始后2.5、3和4小时，正常肺（肺泡）组织中CMNX的平均浓度分别为28.80、26.50和17.80微克/克，细支气管组织的相应水平分别为19.6、18.40和20.53微克/克。给药开始后2、3和4小时，正常肺（肺泡）组织中PIPC的平均浓度分别为18.97、7.34和5.0微克/克，细支气管组织的相应水平分别为7.2、9.20和低于0.2微克/克。PIPC在肺门淋巴结组织和阻塞性肺炎性病变中也显示出良好的转移。两种药物向肺组织的转移表明，这两种药物都可用于治疗呼吸道传染病和预防术后感染。
