Hongo M, Shimizu R, Sakae K, Hayashi S, Mitsui Y, Ando M
Jpn J Antibiot. 1985 May;38(5):1311-7.
One gram of cefminox (CMNX, MT-141) was injected intravenously to a total of 29 patients prior to abdominal total hysterectomy and drug levels in the uterine and adnexal tissues were bioassayed. Serum samples and uterine tissues were taken at 0.25, 0.5, 1, 2, 4 or 6 hours after the administration, when bilateral uterine arteries were clamped. As to serum levels no difference has seen between cubital venous serum and uterine arterial serum, the half-lives being 2.32 hours and 2.22 hours, respectively. The peak level was 66.7 micrograms/ml for both. The drug level in tissues reached its peak at 15 minutes in the myometrium and cervix uteri, at 30 minutes in the endometrium, portio vaginalis and oviduct and at 1 hour in the ovary. The mean peak level was the highest for the oviduct (55.3 micrograms/g), followed by the portio vaginalis (47.7 micrograms/g), the cervix uteri (46.2 micrograms/g), the myometrium (42.8 micrograms/g), the ovary (37.3 micrograms/g) and the endometrium (34.2 micrograms/g) in this order. After reached the highest levels, the tissue levels decreased gradually in the same manner as the serum levels. From these results it was shown that CMNX is well transferred into various female genital tissues to achieve concentrations higher than MICs for organisms isolated clinically with high incidences in the field of gynecology and obstetrics. It was assumed from these results that CMNX is clinically useful enough in the treatment of genital organ infections.
在29例患者行腹式全子宫切除术之前，静脉注射1克头孢米诺（CMNX，MT - 141），并对子宫和附件组织中的药物水平进行生物测定。给药后0.25、0.5、1、2、4或6小时，当双侧子宫动脉被夹闭时，采集血清样本和子宫组织。关于血清水平，肘静脉血清和子宫动脉血清之间未见差异，半衰期分别为2.32小时和2.22小时。两者的峰值水平均为66.7微克/毫升。组织中的药物水平在子宫肌层和子宫颈15分钟时达到峰值，在子宫内膜、阴道部和输卵管30分钟时达到峰值，在卵巢1小时时达到峰值。平均峰值水平以输卵管最高（55.3微克/克），依次为阴道部（47.7微克/克）、子宫颈（46.2微克/克）、子宫肌层（42.8微克/克）、卵巢（37.3微克/克）和子宫内膜（34.2微克/克）。达到最高水平后，组织水平与血清水平一样逐渐下降。从这些结果表明，CMNX能很好地转移到各种女性生殖组织中，达到高于妇产科临床分离出的常见病原体的最低抑菌浓度（MIC）的浓度。从这些结果推测，CMNX在治疗生殖器官感染方面临床上足够有用。
