Hamasaki N
Department of Clinical Chemistry and Laboratory Medicine, Fukuoka University School of Medicine.
Nihon Rinsho. 1992 Sep;50(9):2069-76.
Band 3 protein is the major transmembrane protein of the erythrocyte membrane, comprising 25% of the total membrane protein and existing at 10(6) copies per cell, and mediates the rapid exchange of anions across the membrane. The exchange of Cl- for HCO3- anions plays an important role on the regulation of oxygen and bicarbonate delivary to or from peripheral tissues. Band 3 protein has functionally distinct two domains. The membrane-spanning domain, 55K domain, is believed to span the membrane bilayer 14 times and mediates the rapid anion exchange. The complementary cytosolic domain, 40K domain, is an anchor for the cytoskeletal proteins and regulates the cell deformability and the cell life span. The purpose of this paper is to review the physiological functions of band 3 protein and the anion exchange mechanisms.
带3蛋白是红细胞膜的主要跨膜蛋白，占膜蛋白总量的25%，每个细胞有10⁶个拷贝，介导阴离子跨膜的快速交换。氯离子与碳酸氢根离子的交换在调节氧气和碳酸氢根向周围组织的输送或从周围组织的输出中起重要作用。带3蛋白有两个功能不同的结构域。跨膜结构域，即55K结构域，被认为14次跨越膜双层并介导快速阴离子交换。互补的胞质结构域，即40K结构域，是细胞骨架蛋白的锚定物，调节细胞的变形能力和细胞寿命。本文旨在综述带3蛋白的生理功能及阴离子交换机制。
