Asker A F, Whitworth C W
Pharmazie. 1976;31(10):728-30.
Complex formation between salicylic acid and adenosine or adenosine triphosphate in 0.2m phosphate buffer at pH=7 was investigated as a potential factor contributing to the prolongation of acetylsalicylic acid-induced GI blood loss. Spectrophotemetric techniques were used to evalute the complexation. Concerntration dependency of the absorbance decrease was measured at 27 and 37 degrees C. The addition of salicylic acid to either adenosine or adenosine triphosplate solutions appeared also to cause a decrease in surface tension which may play a role in reducing platelet aggregation induced by adenosine diphosphate. The results obtained seem to support the opinion that the mechansim of acetylsalicylic acid-induced GI blood loss is due to a combination of both local and systemic effect.
研究了在pH = 7的0.2m磷酸盐缓冲液中水杨酸与腺苷或三磷酸腺苷之间的复合物形成，这是导致乙酰水杨酸引起的胃肠道失血延长的一个潜在因素。采用分光光度技术评估络合作用。在27和37摄氏度下测量吸光度降低的浓度依赖性。向腺苷或三磷酸腺苷溶液中添加水杨酸似乎也会导致表面张力降低，这可能在减少二磷酸腺苷诱导的血小板聚集方面发挥作用。所得结果似乎支持这样一种观点，即乙酰水杨酸引起的胃肠道失血机制是局部和全身作用共同作用的结果。
