Yano K, Nishida M, Suzuki T
Second Department of Surgery, Yamaguchi University School of Medicine, Japan.
J Surg Res. 1992 Nov;53(5):470-4. doi: 10.1016/0022-4804(92)90092-e.
Hepatic hemodynamics before vascular occlusion and the effect of transient hepatic artery or portal vein occlusion on the liver were investigated in normal dogs and dogs with experimentally induced obstructive jaundice by measurement of hepatic tissue blood flow (HTBF), index of hemoglobin concentration (IHb), oxygen saturation (ISO2), serum glutamic pyruvic transaminase (SGPT) concentration, and malonaldehyde (MDA) concentration in liver tissue. Livers with obstructive jaundice had increased blood flow and a lower hemoglobin concentration compared with normal livers at baseline before vascular occlusion. Percentage change of ISO2 from baseline was higher than percentage change of HTBF after reperfusion in both normal and obstructive jaundiced liver, although they were decreased to almost similar proportions during vascular occlusion. MDA concentration in obstructive jaundice after reperfusion following vascular occlusion was higher than in normal liver. Furthermore, MDA concentration after reperfusion following hepatic artery occlusion was increased compared with after reperfusion following portal venous occlusion in obstructive jaundice. There was no evidence of massive liver necrosis which was newly developed by transient vascular occlusion. These results represent the pathological condition in the liver before transient vascular occlusion and after reperfusion in obstructive jaundice.
通过测量肝组织血流量（HTBF）、血红蛋白浓度指数（IHb）、氧饱和度（ISO2）、血清谷丙转氨酶（SGPT）浓度以及肝组织中丙二醛（MDA）浓度，研究了正常犬和实验性诱导梗阻性黄疸犬在血管闭塞前的肝脏血流动力学以及短暂性肝动脉或门静脉闭塞对肝脏的影响。与血管闭塞前基线时的正常肝脏相比，梗阻性黄疸肝脏的血流量增加，血红蛋白浓度降低。在正常肝脏和梗阻性黄疸肝脏中，再灌注后ISO2相对于基线的百分比变化均高于HTBF的百分比变化，尽管在血管闭塞期间它们下降到几乎相似的比例。血管闭塞后再灌注时，梗阻性黄疸中的MDA浓度高于正常肝脏。此外，在梗阻性黄疸中，肝动脉闭塞后再灌注时的MDA浓度高于门静脉闭塞后再灌注时的MDA浓度。没有证据表明短暂性血管闭塞会引发新的大规模肝坏死。这些结果代表了梗阻性黄疸中短暂性血管闭塞前及再灌注后肝脏的病理状况。
