Ujita T, Nonami T, Kurokawa T, Kobayashi H, Takagi H
Department of Surgery II, Nagoya University School of Medicine, Japan.
Eur Surg Res. 1994;26(3):149-55. doi: 10.1159/000129330.
Hepatic hemodynamics, oxygen metabolism, and lactate metabolism during hepatic artery occlusion and reperfusion with and without supplemental oxygen and dobutamine (DOB) were studied in dogs. After a 60-min occlusion, hepatic arterial blood flow recovered about 80% of the preocclusion values after 10 min of reperfusion. However, portal vein blood flow gradually decreased during both occlusion and reperfusion. The partial pressure of oxygen in the portal vein blood (PPVO2) did not change significantly during the experiment. Accordingly, hepatic oxygen (HO2) delivery and consumption (HVO2) decreased markedly during occlusion and did not recover completely after 60 min of reperfusion. Although inhalation of 100% oxygen did not affect hepatic hemodynamics, it markedly increased PPVO2. DOB did not effectively increase PPVO2 though it increased portal vein flow (PVF). Both inhalation of 100% oxygen and DOB infusion enhanced HO2 delivery and HVO2 during hepatic artery occlusion and reperfusion. The hepatic lactate uptake was limited in the control group, however, it was improved by 100% oxygen and, especially, DOB both during occlusion and reperfusion. These data support the conclusion that inhalation of 100% oxygen and DOB administration effectively support hepatic function during hepatic artery occlusion.
研究了在有或没有补充氧气及多巴酚丁胺（DOB）的情况下，犬肝动脉闭塞和再灌注期间的肝脏血流动力学、氧代谢和乳酸代谢。闭塞60分钟后，再灌注10分钟时肝动脉血流量恢复至闭塞前值的约80%。然而，在闭塞和再灌注期间门静脉血流量逐渐减少。实验期间门静脉血中的氧分压（PPVO2）无显著变化。因此，肝脏氧（HO2）输送和消耗（HVO2）在闭塞期间显著降低，再灌注60分钟后未完全恢复。尽管吸入100%氧气不影响肝脏血流动力学，但它显著提高了PPVO2。DOB虽增加了门静脉血流量（PVF），但未有效提高PPVO2。在肝动脉闭塞和再灌注期间，吸入100%氧气和输注DOB均增强了HO2输送和HVO2。对照组肝脏乳酸摄取受限，然而，在闭塞和再灌注期间，100%氧气尤其是DOB使其得到改善。这些数据支持以下结论：吸入100%氧气和给予DOB在肝动脉闭塞期间有效支持肝功能。
