Martín N, Bardisa L, Pantoja C, Román R, Vargas M
Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.
J Ethnopharmacol. 1992 Sep;37(2):145-9. doi: 10.1016/0378-8741(92)90072-y.
The objectives of this work were to investigate the effects of a garlic dialysate on diastolic blood pressure (DBP), heart rate (HR) and electrocardiogram (ECG) of anaesthetized dogs and its effects on frequency and tension of isolated rat atria. Garlic dialysate led to a drop in DBP (from 112.5 +/- 3.67 to 70 +/- 3.16 mmHg) and a decrease in HR (from 198 +/- 9.81 to 164 +/- 16.59 beats/min) in a dose-dependent manner. The ECG showed a regular sinus bradycardic rhythm. The addition of garlic dialysate to isolated left rat atria evoked a decrease in tension development. Frequency, measured by spontaneous beating of the right atria, was also reduced. Both effects were dose-dependent. In addition to these effects, the positive inotropism and chronotropism induced by addition of isoproterenol 10(-9) M, were partially antagonized by preincubation of the rat atria with the garlic dialysate. The above findings can be explained by a depressant effect on automaticity and tension development in the heart, suggesting a beta-adrenoceptor blocking action produced by the garlic dialysate.
本研究的目的是探讨大蒜透析液对麻醉犬舒张压（DBP）、心率（HR）和心电图（ECG）的影响，以及对离体大鼠心房频率和张力的影响。大蒜透析液可使DBP呈剂量依赖性下降（从112.5±3.67 mmHg降至70±3.16 mmHg），HR降低（从198±9.81次/分钟降至164±16.59次/分钟）。心电图显示为规则的窦性心动过缓节律。向离体大鼠左心房添加大蒜透析液可引起张力发展下降。通过右心房自发搏动测量的频率也降低。两种效应均呈剂量依赖性。除了这些效应外，预先用大蒜透析液孵育大鼠心房可部分拮抗10(-9) M异丙肾上腺素诱导的正性肌力作用和变时作用。上述发现可以通过对心脏自律性和张力发展的抑制作用来解释，提示大蒜透析液产生了β-肾上腺素能受体阻断作用。
