Martín N, Bardisa L, Pantoja C, Vargas M, Quezada P, Valenzuela J
Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
J Ethnopharmacol. 1994 Jun;43(1):1-8. doi: 10.1016/0378-8741(94)90109-0.
The effects of garlic (Allium sativum L., Liliaceae) dialysate were studied on arrhythmias induced in anaesthetized dogs and on isolated left rat atria. Garlic dialysate suppressed premature ventricular contractions (PVC) and ventricular tachycardia (VT) in ouabain-intoxicated dogs as well as the ectopic rhythms induced by isoprenaline (10(-6) M) and aconitine (10(-8) M) on electrically driven left rat atria. The effective refractory period (ERP) and the sinus node recovery time (SNRT) of isolated rat atria were prolonged in a dose-dependent manner by the administration of this extract. Garlic dialysate decreased the positive inotropic and chronotropic effects of isoprenaline in a concentration-dependent manner. These last effects were increased by propranolol. The results suggest that garlic dialysate has a significant antiarrhythmic effect in both ventricular and supraventricular arrhythmias.
研究了大蒜（百合科葱属植物大蒜）透析液对麻醉犬诱发的心律失常以及对离体大鼠左心房的影响。大蒜透析液可抑制哇巴因中毒犬的室性早搏（PVC）和室性心动过速（VT），以及异丙肾上腺素（10⁻⁶ M）和乌头碱（10⁻⁸ M）对电驱动的大鼠左心房诱发的异位节律。给予该提取物后，离体大鼠心房的有效不应期（ERP）和窦房结恢复时间（SNRT）呈剂量依赖性延长。大蒜透析液以浓度依赖性方式降低异丙肾上腺素的正性肌力和变时作用。普萘洛尔可增强这些最后的作用。结果表明，大蒜透析液对室性和室上性心律失常均具有显著的抗心律失常作用。
