Adner N, Nygren A
Department of Medicine II, Södersjukhuset, Stockholm, Sweden.
Metabolism. 1992 Nov;41(11):1165-70. doi: 10.1016/0026-0495(92)90004-t.
The effect of indomethacin, theophylline, and propranolol on ethanol augmentation of insulin secretion after intravenous glucose stimulation was studied. Intravenous glucose tolerance tests were performed with and without pretreatment with oral ethanol. The role of indomethacin was evaluated in six healthy subjects; the effect of theophylline and propranolol on ethanol augmentation in insulin secretion was studied in five and six subjects, respectively. Ethanol pretreatment was followed by increased insulin (P < .01) and C-peptide areas (P < .01) after intravenous glucose (Area, 0 to 20 minutes). Indomethacin suppressed the ability of ethanol to augment insulin (P < .01) and C-peptide (P < .01) responses. Neither theophylline nor propranolol affected ethanol augmentation of insulin secretion. In conclusion, indomethacin probably interferes with the mechanism for ethanol augmentation of glucose-induced insulin secretion. It is suggested that inositol phospholipids take part in the effect of ethanol to augment insulin secretion, and that indomethacin interferes with the metabolism of inositol phospholipids.
研究了吲哚美辛、茶碱和普萘洛尔对静脉注射葡萄糖刺激后乙醇增强胰岛素分泌的影响。在口服乙醇预处理和未预处理的情况下进行静脉葡萄糖耐量试验。对6名健康受试者评估了吲哚美辛的作用；分别对5名和6名受试者研究了茶碱和普萘洛尔对乙醇增强胰岛素分泌的影响。静脉注射葡萄糖（0至20分钟的曲线下面积）后，乙醇预处理使胰岛素（P < 0.01）和C肽曲线下面积（P < 0.01）增加。吲哚美辛抑制了乙醇增强胰岛素（P < 0.01）和C肽（P < 0.01）反应的能力。茶碱和普萘洛尔均未影响乙醇对胰岛素分泌的增强作用。总之，吲哚美辛可能干扰了乙醇增强葡萄糖诱导胰岛素分泌的机制。提示肌醇磷脂参与了乙醇增强胰岛素分泌的作用，且吲哚美辛干扰了肌醇磷脂的代谢。
