Potter D E, Chin C A, Rowland J M
Pharmacology. 1980;20(4):203-10. doi: 10.1159/000137366.
Ethanol suppressed, in a dose-related manner, glucose-induced insulin (IRI) release and thus delayed the disappearance of glucose from the blood of rats. Pretreatment with pyrazole, an alcohol dehydrogenase inhibitor, exacerbated the effect of ethanol on IRI release, glucose tolerance and glucagon (IRG) release. These results suggest that ethanol produces glucose intolerance by inhibiting glucose-induced IRI release and by augmenting IRG release. Moreover, these findings indicate that ethanol does not have to be metabolized completely in order to produce these effects.
乙醇以剂量相关的方式抑制葡萄糖诱导的胰岛素（IRI）释放，从而延迟大鼠血液中葡萄糖的消失。用酒精脱氢酶抑制剂吡唑预处理会加剧乙醇对IRI释放、葡萄糖耐量和胰高血糖素（IRG）释放的影响。这些结果表明，乙醇通过抑制葡萄糖诱导的IRI释放和增强IRG释放而导致葡萄糖不耐受。此外，这些发现表明，乙醇不必完全代谢就能产生这些作用。
