Dündar V, Baran R, Akgül A, Güney C
Haydarpaşa Numune Hastanesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji Kliniği.
Mikrobiyol Bul. 1992 Oct;26(4):320-8.
IgG antibodies against the purified antigen 60 have been detected in the sera of 48 active, 12 inactive pulmonary tuberculosis patients and 46 tuberculosis free controls with ELISA. Diagnostic value of this test has been evaluated in the conditions of our country. The detection of IgG antibodies against antigen 60 has 67% sensitivity, 90% specificity and 81% positive predictive values. It has been decided that these values have no superiority compared to the sputum examination. It was also found out that sensitivity of antigen 60 ELISA IgG test is very low (22%) in the condition of primary pulmonary tuberculosis cases where direct sputum microscopy sensitivity is also very low.
通过酶联免疫吸附测定法(ELISA)在48例活动性肺结核患者、12例非活动性肺结核患者以及46例无结核对照者的血清中检测到了针对纯化抗原60的IgG抗体。在我国的条件下评估了该检测的诊断价值。针对抗原60的IgG抗体检测具有67%的敏感性、90%的特异性和81%的阳性预测值。已确定这些数值与痰检相比并无优势。还发现,在原发性肺结核病例中,抗原60 ELISA IgG检测的敏感性非常低(22%),而直接痰涂片显微镜检查的敏感性也很低。