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浅表全身电子线治疗中实现均匀剂量分布的问题与解决方案

Problems and solutions in achieving uniform dose distribution in superficial total body electron therapy.

作者信息

Kumar P P, Henschke U K, Nibhanupudy J R

出版信息

J Natl Med Assoc. 1977 Sep;69(9):645-7.

PMID:143541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2536947/
Abstract

In treating mycosis fungoides (MF) and Sezary syndrome patients with electron beam, the entire thickness and the area of the skin from crown to sole should be irradiated uniformly. To achieve irradiation of the entire thickness of the skin, electron beams of 3 - 4 MeV energy with 80 percent depth dose at 6 mm is sufficient. This unique property of limited penetration of electron beam does not cause any systemic toxicity during or after total body electron therapy. However, this property of limited penetration of electrons poses the problem of self-shielding in the curvaceous human body. The optic lens, which is within the range of penetrability of electron beam energy used for total body electron therapy, is to be shielded artificially.The purpose of this paper is to discuss the problems of self and artificial shielding in the superficial total body electron therapy for MF and Sezary syndrome.

摘要

在用电子束治疗蕈样肉芽肿(MF)和塞扎里综合征患者时,应均匀照射从头顶到脚底的整个皮肤厚度和面积。为实现对整个皮肤厚度的照射,能量为3 - 4 MeV、在6 mm处深度剂量为80%的电子束就足够了。电子束穿透有限的这一独特特性在全身电子治疗期间或之后不会引起任何全身毒性。然而,电子穿透有限的这一特性在人体曲线部位会造成自屏蔽问题。用于全身电子治疗的电子束能量可穿透范围内的晶状体需要进行人工屏蔽。本文旨在探讨MF和塞扎里综合征浅表全身电子治疗中的自屏蔽和人工屏蔽问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/5356bceb5fb2/jnma00007-0041-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/9ff8dac0430d/jnma00007-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/112541128c18/jnma00007-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/1e022b2e5466/jnma00007-0040-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/6ed681763d72/jnma00007-0040-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/bb8fb56a5810/jnma00007-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/fc8ea0202e5e/jnma00007-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/5356bceb5fb2/jnma00007-0041-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/9ff8dac0430d/jnma00007-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/112541128c18/jnma00007-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/1e022b2e5466/jnma00007-0040-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/6ed681763d72/jnma00007-0040-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/bb8fb56a5810/jnma00007-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/fc8ea0202e5e/jnma00007-0041-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef7/2536947/5356bceb5fb2/jnma00007-0041-c.jpg

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本文引用的文献

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10 mev. betatron electron beam therapy adapted to a case of mycosis fungoides.适用于蕈样肉芽肿病例的10兆电子伏电子感应加速器电子束疗法
Am J Roentgenol Radium Ther Nucl Med. 1962 Aug;88:229-34.
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Ten year experience with low megavolt ellectron therapy.低兆伏电子线治疗的十年经验
Am J Roentgenol Radium Ther Nucl Med. 1962 Aug;88:215-28.
3
High energy electrons for the treatment of extensive superficial malignant lesions.用于治疗广泛浅表恶性病变的高能电子。
螺旋弧形放射疗法治疗皮肤癌。
Int J Mol Sci. 2023 Feb 24;24(5):4492. doi: 10.3390/ijms24054492.
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In-vivo dosimetric analysis in total skin electron beam therapy.全身皮肤电子束治疗中的体内剂量分析
Phys Imaging Radiat Oncol. 2018 May 19;6:61-65. doi: 10.1016/j.phro.2018.05.002. eCollection 2018 Apr.
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A case report of total skin photon radiation therapy for cutaneous epitheliotropic lymphoma in a dog.一例犬皮肤上皮样淋巴瘤全皮肤光子放射治疗的病例报告。
BMC Vet Res. 2019 Nov 9;15(1):407. doi: 10.1186/s12917-019-2105-4.
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Characterization of a non-contact imaging scintillator-based dosimetry system for total skin electron therapy.用于全身电子治疗的非接触成像闪烁体剂量测定系统的特性描述。
Phys Med Biol. 2019 Jun 21;64(12):125025. doi: 10.1088/1361-6560/ab1d8a.
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Rapid Multisite Remote Surface Dosimetry for Total Skin Electron Therapy: Scintillator Target Imaging.快速多点远程表面剂量测定在全身皮肤电子治疗中的应用:闪烁体靶成像。
Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):767-774. doi: 10.1016/j.ijrobp.2018.10.030. Epub 2018 Nov 10.
8
Dose optimization of total or partial skin electron irradiation by thermoluminescent dosimetry.应用热释光剂量测量对全身或局部皮肤电子照射进行剂量优化。
Strahlenther Onkol. 2018 May;194(5):444-453. doi: 10.1007/s00066-018-1263-9. Epub 2018 Jan 19.
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Total skin electron irradiation techniques: a review.全身皮肤电子线照射技术:综述
Postepy Dermatol Alergol. 2013 Feb;30(1):50-5. doi: 10.5114/pdia.2013.33379. Epub 2013 Feb 20.
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