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霍华德大学医院使用18兆电子伏特直线加速器治疗蕈样肉芽肿的早期经验。

Early experience in using and 18 Me V linear accelerator for mycosis fungoides at Howard University Hospital.

作者信息

Kumar P P, Henschke K, Mandal K P, Nibhanupudy J R, Patel I S

出版信息

J Natl Med Assoc. 1977 Apr 1;69(4):223-6.

PMID:404433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2538398/
Abstract

This paper describes the problems and solutions in using 18 MeV linear accelerator, with minimum 6 MeV electron capability, for total skin irradiation for mycosis fungoides. The 6 MeV electron energy can be degraded to acceptable electron energy of 3.2 MeV by interposing a plexiglass sheet of 9.6 mm in the beam. To minimize the bremsstrahlung, the degrading plexiglass should be kept away from the machine head. A wide area with uniform dose distribution over single plane can be achieved by using dual fields but homogenous dose distribution over irregular body surface cannot be achieved mainly because of self-shielding. The nails and the ocular lens can be easily shielded from the low energy electrons with 1.5 mm lead shield.

摘要

本文描述了使用具有至少6 MeV电子能量的18 MeV直线加速器进行蕈样肉芽肿全身皮肤照射时的问题及解决方案。通过在射束中插入一块9.6 mm的有机玻璃板,6 MeV的电子能量可降至可接受的3.2 MeV电子能量。为使轫致辐射最小化,降解用的有机玻璃板应远离机头。使用双野可在单平面上实现剂量分布均匀的大面积照射,但主要由于自身屏蔽,无法在不规则体表上实现均匀的剂量分布。用1.5 mm的铅屏蔽可轻松将指甲和晶状体与低能电子屏蔽开。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/2538398/476e67c32874/jnma00003-0028-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/2538398/17585234a728/jnma00003-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/2538398/476e67c32874/jnma00003-0028-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/2538398/17585234a728/jnma00003-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7ea/2538398/476e67c32874/jnma00003-0028-b.jpg

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1
Early experience in using and 18 Me V linear accelerator for mycosis fungoides at Howard University Hospital.霍华德大学医院使用18兆电子伏特直线加速器治疗蕈样肉芽肿的早期经验。
J Natl Med Assoc. 1977 Apr 1;69(4):223-6.
2
Total skin electron irradiation therapy in mycosis fungoides using high-dose rate mode: a preliminary experience.采用高剂量率模式的蕈样肉芽肿全皮肤电子线照射治疗:初步经验
Int J Dermatol. 2005 Oct;44(10):828-30. doi: 10.1111/j.1365-4632.2005.02217.x.
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[Total cutaneous irradiation with low energy electrons and mycosis fungoides. Technic and dosimetry].[低能电子全身皮肤照射与蕈样肉芽肿。技术与剂量测定]
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Mycosis fungoides: electron beam therapy in England.蕈样肉芽肿:英国的电子束治疗
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[Breakdown of the energy of a fixed 7 MeV electron bundle in the treatment of mycosis fungoides (author's transl)].蕈样肉芽肿治疗中固定能量7兆电子伏电子束的能量分解(作者译)
J Radiol Electrol Med Nucl. 1977 Nov;58(11):693-9.
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Whole body electron therapy in mycosis fungoides--a successful translational technique achieved by modification of an established linear accelerator.蕈样肉芽肿的全身电子线治疗——通过对现有直线加速器进行改良实现的一项成功的转化技术。
Br J Radiol. 1979 Apr;52(616):302-7. doi: 10.1259/0007-1285-52-616-302.
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Mycosis fungoides. Electron beam therapy.蕈样肉芽肿。电子束疗法。
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[Total skin irradiation with electrons for mycosis fungoides: criteria for the choice of technique and experimental dosimetry].[蕈样肉芽肿的电子线全身皮肤照射:技术选择及实验剂量学标准]
Radiol Med. 1990 Oct;80(4 Suppl 1):143-6.
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[Total cutaneous electron beam therapy of mycosis fungoides].蕈样肉芽肿的全身皮肤电子束治疗
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Physical aspects of a rotational total skin electron irradiation.
Med Phys. 1983 Mar-Apr;10(2):159-68. doi: 10.1118/1.595296.

引用本文的文献

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Phys Med Biol. 2018 May 2;63(9):095009. doi: 10.1088/1361-6560/aaba19.
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Rotational subtotal skin electron beam therapy for management of carcinoma en cuirasse.旋转式部分皮肤电子束疗法治疗铠甲状癌
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3
Rotation technique for superficial total body electron beam irradiation.浅表全身电子束照射的旋转技术

本文引用的文献

1
10 mev. betatron electron beam therapy adapted to a case of mycosis fungoides.适用于蕈样肉芽肿病例的10兆电子伏电子感应加速器电子束疗法
Am J Roentgenol Radium Ther Nucl Med. 1962 Aug;88:229-34.
2
X-RAY CONTAMINATION IN TOTAL-SKIN ELECTRON THERAPY OF LYMPHOMA CUTIS AND EXFOLIATIVE DERMATITIS.
Radiology. 1965 Aug;85:356-60. doi: 10.1148/85.2.356.
3
Ten year experience with low megavolt ellectron therapy.低兆伏电子线治疗的十年经验
Am J Roentgenol Radium Ther Nucl Med. 1962 Aug;88:215-28.
J Natl Med Assoc. 1978 Jul;70(7):507-9.
4
Problems and solutions in achieving uniform dose distribution in superficial total body electron therapy.浅表全身电子线治疗中实现均匀剂量分布的问题与解决方案
J Natl Med Assoc. 1977 Sep;69(9):645-7.
4
High energy electrons for the treatment of extensive superficial malignant lesions.用于治疗广泛浅表恶性病变的高能电子。
Am J Roentgenol Radium Ther Nucl Med. 1953 Apr;69(4):623-9.
5
Total-skin electron treatment of mycosis fungoides.蕈样肉芽肿的全身皮肤电子线治疗
Radiology. 1971 Jul;100(1):145-50. doi: 10.1148/100.1.145.
6
Patient dosimetry in the electron treatment of large superficial lesions.大的浅表病变电子治疗中的患者剂量测定
Radiology. 1970 Mar;94(3):635-41. doi: 10.1148/94.3.635.
7
Mycosis fungoides: pathologic findings in staging laparotomies.
Cancer. 1974 Jun;33(6):1589-600. doi: 10.1002/1097-0142(197406)33:6<1589::aid-cncr2820330618>3.0.co;2-y.
8
Mycosis fungoides with extracutaneous dissemination: a distinct clinicopathologic entity.蕈样肉芽肿伴皮肤外播散:一种独特的临床病理实体。
Cancer. 1974 Nov;34(5):1745-55. doi: 10.1002/1097-0142(197411)34:5<1745::aid-cncr2820340524>3.0.co;2-w.
9
Mycosis fungoides: the pathology of extracutaneous involvement.蕈样肉芽肿:皮肤外受累的病理学
Cancer. 1974 Oct;34(4):1198-229. doi: 10.1002/1097-0142(197410)34:4<1198::aid-cncr2820340431>3.0.co;2-e.
10
Total-skin electron-beam therapy of lymphoma cutis and generalized psoriasis: clinical experiences and adverse reactions.蕈样肉芽肿和泛发性银屑病的全身电子束治疗:临床经验与不良反应
Radiology. 1966 Nov;87(5):908-15 passim. doi: 10.1148/87.5.908.