[新型抗寄生虫药物的研究。11. 新型驱虫药替扎诺克斯与阿齐诺克斯相比的急性毒性和抗绦虫活性]
[The search for new antiparasitic agents. 11. The acute toxicity and anticestodal activity of the new anthelmintic Tizanox compared with Azinox].
作者信息
Mikhaĭlitsyn F S, Kovalenko F P, Sergovskaia N L, Lebedeva M N, Dzhabarova V I, Lychko N D, Naĭdenova A S
出版信息
Med Parazitol (Mosk). 1992 Mar-Apr(2):32-4.
PMID:1435534
Abstract
A synthesis is described and the results of toxicological trial of the potential anthelmintic agent G-1587 are presented. The agent is 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-2H-[1, 2,5] thiadiazino [3,2-a] isoquinoline-4,4-dioxide. The agent was shown to have a low toxicity, the maximal sublethal dose for mice being 4.0 g/kg when given per os.
摘要
本文描述了一种合成方法，并展示了潜在驱虫剂G-1587的毒理学试验结果。该药剂为2-(环己基羰基)-1,2,3,6,7,11b-六氢-2H-[1,2,5]噻二嗪并[3,2-a]异喹啉-4,4-二氧化物。结果表明该药剂毒性较低，经口给予小鼠时的最大亚致死剂量为4.0 g/kg。
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