• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[抗寄生虫制剂的制造技术。6. 抗蠕虫药阿齐诺克斯（吡喹酮）生产技术的开发及其毒性和驱虫特性评估]

[The technology for manufacturing antiparasitic preparations. 6. The development of a technology for producing the anthelmintic Azinox (praziquantel) and the evaluation of its toxic and anthelmintic properties].

作者信息

Mikhaĭlitsyn F S, Sergovskaia N L, Lebedeva M N, Astaf'ev B A, Gitsu G A, Baiandina D G, Uvarova N A, Lychko N D

出版信息

Med Parazitol (Mosk). 1996 Oct-Dec(4):36-9.

PMID:9026672
Abstract

The paper outlines a procedure for manufacturing the anthelminthic Azinox (biltricide) using the new interfacial transfer catalyst benzyl-di-propyl (beta-hydroxyethyl)ammonium chloride. Azinox has been shown to be identical to biltricide (praziquantel) in its properties. Azinox tests on models of Opisthorchis felineus in golden hamsters and of Hymenolepis nana in albino outbred mice have indicated that the agent is not inferior to biltricide in its antitrematodal and anticestodal activities. Azinox displayed a high activity at the preimaginal stages of O. felineus and H. nana and at the larval stage of H.nana.

摘要

该论文概述了一种使用新型界面转移催化剂苄基 - 二 - 丙基（β - 羟乙基）氯化铵制造驱虫药阿齐诺克斯（吡喹酮）的方法。已证明阿齐诺克斯在性质上与吡喹酮相同。对金黄仓鼠体内的猫后睾吸虫模型和白化远交小鼠体内的微小膜壳绦虫进行的阿齐诺克斯试验表明，该药物在抗吸虫和抗绦虫活性方面不逊色于吡喹酮。阿齐诺克斯在猫后睾吸虫和微小膜壳绦虫的成虫前期阶段以及微小膜壳绦虫的幼虫阶段均表现出高活性。

相似文献

1
[The technology for manufacturing antiparasitic preparations. 6. The development of a technology for producing the anthelmintic Azinox (praziquantel) and the evaluation of its toxic and anthelmintic properties].[抗寄生虫制剂的制造技术。6. 抗蠕虫药阿齐诺克斯（吡喹酮）生产技术的开发及其毒性和驱虫特性评估]
Med Parazitol (Mosk). 1996 Oct-Dec(4):36-9.
2
[The technology for manufacturing antiparasitic preparations. 9. The new preparation tizanox and an evaluation of its anti-Hymenolepis activity].[抗寄生虫制剂的制造技术。9. 新型制剂替扎诺克斯及其抗膜壳绦虫活性评估]
Med Parazitol (Mosk). 1999 Jan-Mar(1):49-51.
3
[The search for new antiparasitic agents. 11. The acute toxicity and anticestodal activity of the new anthelmintic Tizanox compared with Azinox].[新型抗寄生虫药物的研究。11. 新型驱虫药替扎诺克斯与阿齐诺克斯相比的急性毒性和抗绦虫活性]
Med Parazitol (Mosk). 1992 Mar-Apr(2):32-4.
4
[The structure and anthelmintic action of tricyclic analogs of praziquantel and 4-acylpiperazinones-2].
Med Parazitol (Mosk). 1991 Nov-Dec(6):50-2.
5
[The results of an experimental study of an anti-Opisthorchis preparation made from plant raw material].[由植物原料制成的抗后睾吸虫制剂的实验研究结果]
Med Parazitol (Mosk). 1996 Jul-Sep(3):42-5.
6
[The technology for manufacturing antiparasitic preparations. 5. The development of a technology for producing the anthelmintic triclonate and the evaluation of its therapeutic efficacy in monieziasis].[抗寄生虫制剂的制造技术。5. 抗蠕虫药三氯苯达唑生产技术的开发及其对莫尼茨绦虫病治疗效果的评估]
Med Parazitol (Mosk). 1996 Jan-Mar(1):27-9.
7
[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines].
Med Parazitol (Mosk). 1994 Jul-Sep(3):41-4.
8
[Synthesis and anthelmintic activity of praziquantel analogs].吡喹酮类似物的合成与驱虫活性
Med Parazitol (Mosk). 1985 Nov-Dec(6):43-7.
9
[The technology for manufacturing antiparasitic preparations. 4. The development of a technology for producing the anthelmintic bromoksan in finely dispersed form and the evaluation of its antifascioliasis activity].[抗寄生虫制剂的制造技术。4. 生产细分散形式驱虫药溴克生的技术开发及其抗片形吸虫病活性评估]
Med Parazitol (Mosk). 1995 Jul-Sep(3):41-2.
10
[Comparative effectiveness of praziquantel and chloxyl in experimental opisthorchiasis in golden hamsters].[吡喹酮和氯羟喹在金黄仓鼠实验性华支睾吸虫病中的疗效比较]
Med Parazitol (Mosk). 1982 Mar-Apr;60(2):52-4.