Mendoza L, Villalobos J, Calleja C E, Solis A
Department of Microbiology, Escuela de Medicina Veterinaria Universidad Nacional, Heredia, Costa Rica.
Mycopathologia. 1992 Aug;119(2):89-95. doi: 10.1007/BF00443939.
Two vaccines to treat phythiosis insidiosi in horses were evaluated in 71 Costa Rican horses between 1982 to 1988. One vaccine used a cell-mass (CMV) as antigen and the other a soluble concentrated antigen (SCAV). Both vaccines cured horses infected with Pythium insidiosum (p value approximately 14%). The age of lesions prior to vaccination was important in the response of the horses to immunotherapy. All horses with lesions 0.5 months or less in duration were cured regardless of the vaccine used. Horses with lesions two or more months old did not respond to either vaccine. The age of the horses did not have any influence on their response to the vaccinations. The CMV produced a prominent inflammatory reaction at the side of injection, while the SCAV gave a low inflammatory reaction. In addition, the CMV lost its effectiveness two to three weeks after its preparation. By contrast, the SCAV maintained its ability to cure horses even after 18 months. Immunotherapy using SCAV can thus be used as the vaccine of choice in early cases of equine cutaneous pythiosis insidiosi.
1982年至1988年间，在71匹哥斯达黎加马身上评估了两种用于治疗马类隐孢子虫病的疫苗。一种疫苗使用细胞团（CMV）作为抗原，另一种使用可溶性浓缩抗原（SCAV）。两种疫苗都治愈了感染瓜亡革菌的马（p值约为14%）。接种疫苗前病变的时长对于马对免疫疗法的反应很重要。所有病程持续0.5个月或更短时间的马，无论使用哪种疫苗都被治愈了。病程长达两个月或更长时间的马对两种疫苗均无反应。马的年龄对其对疫苗接种的反应没有任何影响。CMV在注射部位产生了明显的炎症反应，而SCAV引起的炎症反应较弱。此外，CMV在制备后两到三周就失去了效力。相比之下，SCAV即使在18个月后仍保持治愈马的能力。因此，使用SCAV进行免疫疗法可作为马皮肤隐孢子虫病早期病例的首选疫苗。
