Swaminathan S, Furey W, Pletcher J, Sax M
Biocrystallography Laboratory, VA Medical Center, Pittsburgh, Pennsylvania 15240.
Nature. 1992 Oct 29;359(6398):801-6. doi: 10.1038/359801a0.
The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a super-antigen, has been determined to a resolution of 2.5 A. The unusual main-chain fold containing two domains may represent a general motif adopted by all staphylococcal enterotoxins. The T-cell receptor binding site encompasses a shallow cavity formed by both domains. The MHCII molecule binds to an adjacent site. Another cavity with possible biological activity was also identified.
