Tempia A, Livigni S, Castino P M, Fiore G, De Caroli D, Pattono R
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Torino.
Minerva Anestesiol. 1992 Sep;58(9):547-51.
Chlorhydrate nefopam was used in the prophylaxis and treatment of postoperative shivering in 54 patients undergoing general anesthesia for radical cystectomy with trans-intestinal anastomosis. Postoperative shivering was not observed in any of the patients treated with nefopam before coming round, whereas it occurred in 55% of patients treated with placebo. Chlorhydrate nefopam subsequently stopped shivering in all these patients. The main side effects observed took the form of delayed awakening in 11% of patients receiving prophylactic treatment and somnolence lasting 5-10 minutes in all other patients.
盐酸奈福泮用于预防和治疗54例接受经肠吻合根治性膀胱切除术全身麻醉患者的术后寒战。在苏醒前，接受盐酸奈福泮治疗的患者均未出现术后寒战，而接受安慰剂治疗的患者中有55%出现了术后寒战。随后，盐酸奈福泮使所有这些患者的寒战停止。观察到的主要副作用表现为：接受预防性治疗的患者中有11%出现苏醒延迟，其他所有患者出现持续5 - 10分钟的嗜睡。
