双重辣椒素敏感传入通路介导肠道碳水化合物诱导的大鼠胃排空抑制。

Dual capsaicin-sensitive afferent pathways mediate inhibition of gastric emptying in rat induced by intestinal carbohydrate.

作者信息

Raybould H E, Hölzer H

机构信息

Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles, CA 90073.

出版信息

Neurosci Lett. 1992 Jul 20;141(2):236-8. doi: 10.1016/0304-3940(92)90902-j.

DOI:10.1016/0304-3940(92)90902-j

PMID:1436639

Abstract

The role of the vagal and spinal afferent innervation in the inhibition of gastric emptying induced by duodenal perfusion with a disaccharide (maltose 300 mM) was investigated in awake rats fitted with gastric and duodenal cannulas. Perfusion of the duodenum with maltose inhibited gastric emptying by 44%. Maltose-induced inhibition of gastric emptying was reversed by 46% and 100% by functional ablation of the vagal or spinal capsaicin-sensitive afferent innervation, respectively. Pretreatment with the specific CCK 'A' receptor antagonist, MK329, completely abolished the effects of maltose on gastric emptying. These results suggest that disaccharides inhibit gastric emptying via activation of capsaicin-sensitive afferents in the duodenal mucosa via a mechanism involving an action of CCK at type 'A' receptors, possibly located on afferent fibers.

摘要

在安装了胃和十二指肠插管的清醒大鼠中，研究了迷走神经和脊髓传入神经支配在十二指肠灌注二糖（300 mM麦芽糖）诱导的胃排空抑制中的作用。用麦芽糖灌注十二指肠可使胃排空抑制44%。分别通过功能性切除迷走神经或脊髓辣椒素敏感传入神经支配，麦芽糖诱导的胃排空抑制分别逆转了46%和100%。用特异性CCK“A”受体拮抗剂MK329预处理可完全消除麦芽糖对胃排空的影响。这些结果表明，二糖通过激活十二指肠黏膜中辣椒素敏感传入神经，通过一种涉及CCK作用于“A”型受体（可能位于传入纤维上）的机制来抑制胃排空。