Ferrell W R, Lam F Y, Montgomery I
Institute of Physiology, University of Glasgow, UK.
Neurosci Lett. 1992 Jul 20;141(2):259-61. doi: 10.1016/0304-3940(92)90908-p.
This study was used to examine the ultrastructure of articular nerves supplying the medial aspect of the rat knee joint following injection of capsaicin into the synovial cavity. One week after the intra-articular injection of 0.2 ml of 1% capsaicin solution there was significant reduction in the number of unmyelinated fibres. Two weeks post-injection this appeared to recover and by 4 weeks post-injection no further changes were observed. Myelinated fibres were unaffected by capsaicin injection. This procedure provides an effective means of producing short-term degeneration of unmyelinated fibres innervating the knee joint.
本研究旨在通过向大鼠膝关节滑膜腔内注射辣椒素，来检测供应膝关节内侧的关节神经的超微结构。关节腔内注射0.2 ml 1%辣椒素溶液一周后，无髓纤维数量显著减少。注射两周后，数量似乎有所恢复，到注射四周时未观察到进一步变化。有髓纤维不受辣椒素注射的影响。该方法为使支配膝关节的无髓纤维发生短期退变提供了一种有效手段。
