Scadding J W
J Anat. 1980 Oct;131(Pt 3):471-82.
The effects of neonatal capsaicin on the fibre populations of peripheral somatosensory nerves have been investigated in adult mouse sural nerve and rat saphenous nerve. One or two doses of capsaicin, 50 mg/kg, given in the first few days of life, caused a permanent 50% reduction in the number of unmyelinated axons in mouse sural nerve and a 64% reduction in rat saphenous nerve, compared with untreated controls. Schwann cell sub-units were also reduced in number, and on average contained fewer axons than controls. The number and size distribution of myelinated fibres were not affected by capsaicin. Active degeneration was seen in only a few unmyelinated axons, and a small number of denervated Schwann cell bands was present. There were no signs of unmyelinated fibre regeneration. It is concluded that neonatal capsaicin produces selective degeneration of unmyelinated axons in the neonatal period which has effectively reached its full extent by early adult life.
在成年小鼠腓肠神经和大鼠隐神经中，研究了新生期辣椒素对周围躯体感觉神经纤维群的影响。在出生后的头几天给予一剂或两剂50mg/kg的辣椒素，与未处理的对照组相比，小鼠腓肠神经中无髓鞘轴突数量永久性减少50%，大鼠隐神经中减少64%。雪旺细胞亚单位数量也减少，且平均所含轴突比对照组少。有髓纤维的数量和大小分布不受辣椒素影响。仅在少数无髓鞘轴突中可见活跃的变性，存在少量去神经支配的雪旺细胞带。没有无髓鞘纤维再生的迹象。结论是，新生期辣椒素在新生期可导致无髓鞘轴突的选择性变性，到成年早期这种变性已有效达到其最大程度。
