Hansen J A, Young C W, Whitsett C, Case D C, Jersild C, Good R A, Dupont B
Prog Clin Biol Res. 1977;16:217-27.
HLA typing for 27 A and B locus antigens was performed in 137 Caucasian patients with Hodgkin's disease. A and B locus antigen frequencies were compared for the entire group of patients, for 51 patients studied in a prospective manner and for 62 patients surviving with Hodgkin's disease for more than 5 years. MLC typing (HLA-D) was performed in 51 unselected Caucasian patients using 6 differend HLA-D homozygous test cells which define 3 HLA-D specificity groups (DW2, DW3, and DW4). HLA-AW33 was found in 0.0% of patients and in 5.9% of random Caucasian blood donors at the Sloan--Kettering Institute (X2 equals 7.04, p less than 0.01). HLA-A1 was found to be increased to 35.8% in the entire patient group (N = 137) as compared to 25.4% in 855 random North American Caucasians (X2 = 5.97, p less than 0.02). There was no significant deviation of any A or B locus antigen in relation to sex, histology, age of patient, or duration of survival (newly diagnosed vs 5-year survivors). No significant deviation for either of the 3 common HLA-D determinants (DW2, DW3, or DW4) was observed.
对137例白种人霍奇金病患者进行了27种A和B位点抗原的HLA分型。比较了整个患者组、51例前瞻性研究患者以及62例存活超过5年的霍奇金病患者的A和B位点抗原频率。使用6种不同的HLA-D纯合检测细胞对51例未选择的白种人患者进行了MLC分型（HLA-D），这些细胞定义了3个HLA-D特异性组（DW2、DW3和DW4）。在斯隆-凯特琳研究所，0.0%的患者和5.9%的随机白种人献血者中发现了HLA-AW33（X2 = 7.04，p < 0.01）。在整个患者组（N = 137）中，HLA-A1增加到35.8%，而在855名随机北美白种人中为25.4%（X2 = 5.97，p < 0.02）。任何A或B位点抗原在性别、组织学、患者年龄或生存时间（新诊断患者与5年存活者）方面均无显著偏差。对于3种常见的HLA-D决定簇（DW2、DW3或DW4）中的任何一种，均未观察到显著偏差。
