阿尔茨海默病患者内侧额叶脑沟和脑回中斑块类型的定量分析。

Quantification of plaque types in sulci and gyri of the medial frontal lobe in patients with Alzheimer's disease.

作者信息

McKenzie J E, Gentleman S M, Royston M C, Edwards R J, Roberts G W

机构信息

Department of Anatomy, St. Mary's Hospital Medical School, Imperial College, London, UK.

出版信息

Neurosci Lett. 1992 Aug 31;143(1-2):23-6. doi: 10.1016/0304-3940(92)90224-u.

DOI:10.1016/0304-3940(92)90224-u

PMID:1436671

Abstract

beta-Amyloid protein (beta A4) deposition was characterised in the sulci and gyri of frontal cortex in 14 cases of Alzheimer's disease. A quantitative study was made of two distinct plaque sub-types (diffuse and classic) using immunocytochemistry and image analysis using a discriminant function design. As reported previously more beta A4 was observed in sulci than gyri. Diffuse plaques were more numerous than classic plaques in sulci and gyri (P less than 0.01). Classic plaques were more abundant in the sulci (P less than 0.01). Increased beta A4 deposition in the sulci is accounted for by increased numbers of classic plaques. No correlation was observed between the numbers of diffuse and classic plaques in either region. Our data suggest that the two plaque types form discrete populations and that their evolution is governed by distinct pathophysiological parameters.

摘要

在14例阿尔茨海默病患者中，对额叶皮质沟回中的β-淀粉样蛋白（βA4）沉积进行了特征分析。使用免疫细胞化学和图像分析，通过判别函数设计对两种不同的斑块亚型（弥漫性和典型性）进行了定量研究。如先前报道，在沟中观察到的βA4比回中更多。在沟和回中，弥漫性斑块比典型性斑块更多（P<0.01）。典型性斑块在沟中更为丰富（P<0.01）。沟中βA4沉积增加是由典型性斑块数量增加所致。在任一区域，弥漫性斑块和典型性斑块的数量之间均未观察到相关性。我们的数据表明，这两种斑块类型形成了不同的群体，并且它们的演变受不同的病理生理参数支配。