Rouiller E M, Wan X S, Moret V, Liang F
Institute of Physiology, University of Fribourg, Switzerland.
Neurosci Lett. 1992 Sep 14;144(1-2):19-24. doi: 10.1016/0304-3940(92)90706-d.
C-fos expression was mapped in the auditory pathways of rats, stimulated acoustically with pure tones. In the cochlear nucleus, two clusters of c-fos-like immunoreactive neurons, located respectively in the caudal part of the dorsal cochlear nucleus and in the granular cell region, did not show clear systematic shift in their position as a function of the tones frequency. On the other hand, more rostrally in the dorsal cochlear nucleus, a cluster of c-fos-like positive neurons moved progressively from dorsal to ventral for decreasing tones frequency. In the posteroventral cochlear nucleus, another cluster of c-fos-like positive neurons was observed, whose position also varied with tones frequency. Surprisingly, no or very rare c-fos-like immunoreactive neurons were present in the anteroventral cochlear nucleus and in the superior olivary complex. In the inferior colliculus, however, c-fos-like immunoreactive neurons formed clear isofrequency contours, shifting from dorsolateral to ventromedial for increasing tones frequency. In the medial geniculate body c-fos-like immunostaining was restricted to the medial and dorsal divisions while the ventral division was free of labeling. The cause of this differential labeling along the auditory pathways is at present unknown but may eventually provide clues as to physiological differences in parallel auditory pathways.
用纯音对大鼠进行听觉刺激，绘制了其听觉通路中的C-fos表达情况。在耳蜗核中，分别位于背侧耳蜗核尾部和颗粒细胞区域的两簇c-fos样免疫反应性神经元，其位置并未随音调频率呈现出明显的系统性变化。另一方面，在背侧耳蜗核更靠前的位置，一簇c-fos样阳性神经元随着音调频率降低逐渐从背侧移向腹侧。在耳蜗后腹核中，观察到另一簇c-fos样阳性神经元，其位置也随音调频率而变化。令人惊讶的是，在耳蜗前腹核和上橄榄复合体中未发现或仅有极少的c-fos样免疫反应性神经元。然而，在下丘中，c-fos样免疫反应性神经元形成了清晰的等频轮廓，随着音调频率增加从背外侧移向腹内侧。在内侧膝状体中，c-fos样免疫染色局限于内侧和背侧部分，而腹侧部分没有标记。目前尚不清楚沿听觉通路这种差异标记的原因，但最终可能为平行听觉通路中的生理差异提供线索。
