Melino G, Stephanou A, Annicchiarico-Petruzzelli M, Finazzi-Agró A, Knight R A, Lightman S L
University of Rome Tor Vergata, Italy.
Neurosci Lett. 1992 Sep 14;144(1-2):25-8. doi: 10.1016/0304-3940(92)90707-e.
A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while alpha-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.
