BUSH J A, BERLIN N I, JENSEN W N, BRILL A B, CARTWRIGHT G E, WINTROBE M M
J Exp Med. 1955 May 1;101(5):451-9. doi: 10.1084/jem.101.5.451.
Red blood cell survival studies were performed on five normal growing swine by following the C(14)-specific activity of hemoglobin and heme after the administration of glycine-2-C(14). The erythrocytes of normal growing swine appear to be destroyed both by a random and an age-dependent process. Random destruction accounts for the larger portion of the cells which are destroyed. The "mean" red cell survival time was 62 days. This represents the interval from the time of incorporation of 50 per cent of the maximal amount of labelling achieved to the time when the level had decreased once more to the 50 per cent amount. The " 'corrected' average potential life span" of the red cells was 86 +/- 11.5 days. This figure was obtained by subtracting the number of days required to attain 80 per cent of the maximal labelling from the average survival time of red cells destroyed by an age-dependent process as distinguished from random destruction.
通过跟踪给予甘氨酸-2-C(14)后血红蛋白和血红素的C(14)比活性，对五只正常生长的猪进行了红细胞存活研究。正常生长猪的红细胞似乎通过随机和年龄依赖性过程被破坏。随机破坏占被破坏细胞的较大部分。“平均”红细胞存活时间为62天。这代表了从达到最大标记量的50%的掺入时间到该水平再次降至50%量的时间间隔。红细胞的“‘校正’平均潜在寿命”为86±11.5天。这个数字是通过从与随机破坏不同的年龄依赖性过程破坏的红细胞的平均存活时间中减去达到最大标记的80%所需的天数而获得的。
