Paugh J R
Allergan Optical, Irvine, California.
Optom Vis Sci. 1992 Oct;69(10):805-10. doi: 10.1097/00006324-199210000-00010.
Although many investigations have examined the parameters of hydrogel lens hydration loss, the in vivo effect (in humans) on lens oxygen behavior has not been characterized previously. Human subjects wore 2 different lenses (a thin, 38% water polymacon lens and a thin, 55% water bufilcon lens) for 5-min periods under either fully hydrated (i.e., with saline regularly applied to the lens) or partially hydrated (i.e., with "normal" wear of 1 blink every 5 s) conditions. An equivalent oxygen percentage (EOP) technique and a gravimetric method were used to determine lens oxygen behavior and hydration, respectively. The hydration results demonstrate that significant lens dehydration occurs during the partially hydrated (normal blink rate) condition compared to the in situ, fully hydrated situation. A corresponding, statistically significant diminution in oxygen equivalency was also observed.
尽管许多研究已经考察了水凝胶镜片水分流失的参数，但此前尚未对其在人体内对镜片氧气行为的体内效应进行表征。人类受试者佩戴两种不同的镜片（一种薄的、含水量38%的聚甲基丙烯酸甲酯镜片和一种薄的、含水量55%的聚硅氧烷丙烯酸酯镜片），在完全水合（即定期向镜片滴注生理盐水）或部分水合（即每5秒“正常”眨眼一次）条件下佩戴5分钟。分别使用等效氧百分比（EOP）技术和重量法来确定镜片的氧气行为和水合情况。水合结果表明，与原位完全水合情况相比，在部分水合（正常眨眼频率）条件下镜片会发生显著脱水。还观察到了相应的、具有统计学意义的氧气等效性降低。
