Efron N, Fitzgerald J P
Eurolens Research, Department of Optometry and Vision Sciences, University of Manchester Institute of Science and Technology, United Kingdom.
Optom Vis Sci. 1996 Oct;73(10):659-65. doi: 10.1097/00006324-199610000-00005.
To determine whether tear mixing occurs beneath soft contact lenses, we examined the effect of blinking on the oxygen distribution across the corneal surface beneath a nonuniform thickness lens.
A custom-designed twin polarographic oxygen sensor assembly was used to simultaneously measure the equivalent oxygen percentage (EOP) at central and peripheral corneal locations of 10 human subjects beneath a -6.00 D thin-design hydroxyethyl mathacrylate (HEMA) lens. A -0.25 D lens served as a control. Each lens was worn for 5 min under static (no blinking) and dynamic (12 and 60 blinks/min) conditions.
A significantly greater EOP (p = 0.006) was observed at the central (vs. peripheral) cornea during static and dynamic lens wear; central and peripheral oxygenation were unaffected by blinking.
Tear mixing is insignificant beneath thin-design HEMA lenses; therefore, oxygenation across the corneal surface beneath such lenses is best predicted from the lens thickness profile rather than average thickness.
为了确定软性接触镜下是否发生泪液混合，我们研究了眨眼对非均匀厚度镜片下角膜表面氧分布的影响。
使用定制设计的双极谱氧传感器组件，同时测量10名人类受试者在-6.00 D薄型甲基丙烯酸羟乙酯（HEMA）镜片下角膜中央和周边位置的等效氧百分比（EOP）。-0.25 D镜片作为对照。每个镜片在静态（不眨眼）和动态（12次和60次/分钟眨眼）条件下佩戴5分钟。
在静态和动态佩戴镜片期间，中央角膜（与周边角膜相比）观察到显著更高的EOP（p = 0.006）；眨眼对中央和周边的氧合没有影响。
薄型HEMA镜片下泪液混合不明显；因此，此类镜片下角膜表面的氧合最好根据镜片厚度分布而非平均厚度来预测。
