Hugo H, Dornbusch K, Sterner G
Scand J Infect Dis. 1977;9(3):221-6. doi: 10.3109/inf.1977.9.issue-3.13.
Clindamycin phosphate was administered intravenously to 41 patients with different types of infections including osteomyelitis, septicaemia and soft tissue infections. All bacterial strains tested showed low MIC values for clindamycin. Maximum serum concentrations after 600 mg intravenously were 6.0--29.0 microgram/ml, after 300 mg intravenously 2.6--26.0 microgram/ml. The therapeutic effect of the drug was considered good in 26 of 31 patients with proven or probable bacterial aetiology. Side effects were noted in 16 of the 41 patients. However, in only 5 of these the treatment had to be terminated, all due to pruritic rashes. In the 7 cases with diarrhoea as side effect, the symptoms were mild and of short duration.
对41例患有不同类型感染（包括骨髓炎、败血症和软组织感染）的患者静脉注射磷酸克林霉素。所有测试的细菌菌株对克林霉素的最低抑菌浓度值都很低。静脉注射600mg后血清最大浓度为6.0 - 29.0微克/毫升，静脉注射300mg后为2.6 - 26.0微克/毫升。在31例已证实或可能由细菌引起病因的患者中，26例患者的药物治疗效果被认为良好。41例患者中有16例出现副作用。然而，其中只有5例患者不得不终止治疗，均是由于瘙痒性皮疹。在7例出现腹泻副作用的病例中，症状轻微且持续时间短。
