Wilson D H
Br J Surg. 1980 Feb;67(2):93-6. doi: 10.1002/bjs.1800670207.
A retrospective survey of 15 019 patients treated with clindamycin for a soft tissue infection was carried out to determine whether the incidence of serious side effects was sufficient to preclude the continuing use of this antibiotic. Thirteen patients were found to have had severe diarrhoea and 2 of these required inpatient treatment for pseudomembranous colitis. Certain limitations of the use of clindamycin are suggested but, in view of the recently improved understanding of the nature of pseudomembranous colitis and more effective methods of treatment of this complication, it is concluded that this antibiotic still has a useful role to play in the treatment of acute soft tissue infection.
对15019例接受克林霉素治疗软组织感染的患者进行了回顾性调查，以确定严重副作用的发生率是否足以排除继续使用这种抗生素。发现13例患者出现严重腹泻，其中2例因伪膜性结肠炎需要住院治疗。文中提出了使用克林霉素的某些局限性，但鉴于最近对伪膜性结肠炎本质的认识有所提高以及治疗这种并发症的更有效方法，得出的结论是，这种抗生素在治疗急性软组织感染中仍可发挥有益作用。
