Koda J, Ludlow C L
Voice and Speech Section, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892.
Otolaryngol Head Neck Surg. 1992 Nov;107(5):684-96. doi: 10.1177/019459989210700510.
Eight patients with voice tremor were studied to characterize laryngeal muscle involvement. Electromyographic (EMG) recordings were made from intrinsic laryngeal muscles, simultaneously with some extrinsic laryngeal muscles, respiratory movement, and voice recordings during respiration, whisper, and phonation. Spectral measures were used to determine the tremor frequency and the prominence of spectral peaks in the EMG, respiratory and acoustic signals, while correlation coefficients were computed between pairs of tremulous EMG signals to measure the synchrony of tremor between muscles. The intrinsic laryngeal muscles were tremulous during respiration and speech, with the thyroarytenoid most often involved. Tremor was also detected in some of the extrinsic muscle recordings and the percentage of muscles with tremor was higher during phonation than during whisper or respiration. Time delays were found between tremor oscillations in laryngeal muscles. Because the thyroarytenoid was affected in all the patients studied, botulinum toxin injections may be beneficial in treatment of this voice disorder.
对8例声音震颤患者进行研究以明确喉肌受累情况。在呼吸、耳语及发声过程中，对喉内肌以及部分喉外肌进行肌电图（EMG）记录，同时记录呼吸运动及声音。采用频谱测量法确定EMG、呼吸及声学信号中的震颤频率和频谱峰值的突出程度，同时计算成对震颤EMG信号之间的相关系数以测量肌肉间震颤的同步性。喉内肌在呼吸和言语过程中出现震颤，最常受累的是甲杓肌。在部分喉外肌记录中也检测到震颤，发声时出现震颤的肌肉百分比高于耳语或呼吸时。发现喉肌震颤振荡之间存在时间延迟。由于在所研究的所有患者中均发现甲杓肌受累，因此肉毒杆菌毒素注射可能有助于治疗这种声音障碍。
