Blanes A, Martinez A, Bujan J, Ramon y Cajal Junquera S, Carballido S M
Virchows Arch A Pathol Anat Histol. 1977 Sep 28;375(3):233-9. doi: 10.1007/BF01102991.
In this study, morphological changes which occur in the small intestine of hypothyroid rats are described. Hypothyroidism was induced during the first 24 h postnataly. - Samples from duodenojejunal and ileocecal junctions were taken, and histologic, histomorphometric, and ultrastructural studies were performed. The most prominent feature was the decrease of the villous height and total mucosal thickness. At electron microscopic level, microvillous height was also markedly decreased. These changes probably represent a direct effect of hormonal deprivation upon the intestinal mucosa, combined with the effect that hypothyroidism may have on the villi.
本研究描述了甲状腺功能减退大鼠小肠中发生的形态学变化。甲状腺功能减退是在出生后最初24小时内诱发的。采集十二指肠空肠和回盲交界处的样本，并进行组织学、组织形态计量学和超微结构研究。最显著的特征是绒毛高度和黏膜总厚度降低。在电子显微镜水平上，微绒毛高度也明显降低。这些变化可能代表激素缺乏对肠黏膜的直接影响，以及甲状腺功能减退可能对绒毛产生的影响。
