Levi A C, Borghi F, Petrino R, Bargoni A, Fronticelli C M, Gentilli S
Dipartimento di Anatomia e Fisiologia Umana, Università di Torino e Italy.
Ital J Gastroenterol. 1991 May;23(4):202-7.
Morphofunctional alterations to the intestinal mucosa are influenced by three main factors: food, bilio-pancreatic secretions, intestinal hormones. In order to assess the importance of each one, histological and histochemical tests were performed on different segments of intestine taken from rats which were sacrificed one month after the following procedure: gastrojejunal anastomosis on a Roux loop (Model I); same procedure plus biliopancreatic bypass into the jejunum (Model II). When compared to the controls, Model I duodenum samples revealed hypertrophy of the entire wall with "bundles" of villi, while Model II samples showed a clear hypotrophy and reduction in the number of duodenal villi. To such modifications of the duodenum correspond longer, thinner villi in the other bowel segments, particularly in the jejunum and distal ileum. These results suggest that the predominant trophic effect derives from contact with biliopancreatic secretions at a proximal level. The modifications of the duodenal mucosa appear to regulate the trophism of the distal segments probably by the secretion of distant acting enterohormones.
食物、胆胰分泌物、肠道激素。为评估每个因素的重要性，对以下操作一个月后处死的大鼠不同肠段进行了组织学和组织化学检测：在Roux袢上行胃空肠吻合术（模型I）；相同操作加上胆胰转流至空肠（模型II）。与对照组相比，模型I十二指肠样本显示整个肠壁肥大，有绒毛“束”，而模型II样本显示十二指肠绒毛明显萎缩且数量减少。十二指肠的此类改变在其他肠段对应着更长、更细的绒毛，尤其是在空肠和回肠末端。这些结果表明，主要的营养作用源自近端与胆胰分泌物的接触。十二指肠黏膜的改变似乎可能通过分泌作用于远处的肠激素来调节远端肠段的营养状态。
