Zukowska B, Kotschy M
Katedry i Zakładu Patofizjologii AM, Bydgoszczy.
Pol Tyg Lek. 1992;47(5-6):120-2.
Authors were interested in blood coagulation proteins and fibrinolysis in blood donors following several plasmaphereses. This interest was related to the occurrence of thrombo-embolic and hemorrhagic complications in these subjects. Blood morphology, serum protein, blood coagulation and fibrinolysis have been examined in 40 healthy blood donors, aged between 19 and 46 years, who gave blood plasma by plasmapheresis technique for 1-59 times. Results did not show any significant changes in blood morphology and serum protein levels prior to and after consecutive plasmaphereses. No significant decrease in blood coagulation proteins and fibrinolysis has been noted. However, a significant increase in factors VIII and IX activities was noted in several blood donors, who underwent the largest number of plasmaphereses. It may predispose these donors to thrombo-embolic complications.
作者对多次进行血浆置换后的献血者的血液凝固蛋白和纤维蛋白溶解情况感兴趣。这种兴趣与这些受试者中血栓栓塞和出血并发症的发生有关。对40名年龄在19至46岁之间的健康献血者进行了血液形态学、血清蛋白、血液凝固和纤维蛋白溶解的检查，这些献血者通过血浆置换技术献血浆1至59次。结果显示，连续进行血浆置换前后，血液形态学和血清蛋白水平没有任何显著变化。血液凝固蛋白和纤维蛋白溶解也没有显著降低。然而，在接受血浆置换次数最多的几名献血者中，发现因子VIII和IX活性显著增加。这可能使这些献血者易发生血栓栓塞并发症。
