Grgicević D
Ric Clin Lab. 1983 Jan-Mar;13(1):21-31.
The influence of serial, double plasmapheresis on blood coagulation was evaluated in two groups of plasma donors that had undergone from 3 to 306 plasmapheresis sessions. Averages of 375 and 660 ml of plasma, respectively, were harvested weekly from the donors. No statistically significant changes were observed in platelet count, activities of factor V and factor VIII, fibrinogen, plasminogen, alpha 2-macroglobulin, antithrombin III and prothrombin time, irrespectively of the frequency and the number of the plasmapheresis sessions. The concentration of alpha 1-antitrypsin was already increased after seven plasmapheresis sessions in both groups of donors. The kaolin-cephalin clotting time was progressively shortened with the increasing volume of harvested plasma (p less than 0.05) and the thrombin time was prolonged (p less than 0.05).
在两组分别进行了3至306次血浆置换的血浆捐献者中，评估了连续两次血浆置换对血液凝固的影响。每周分别从捐献者中采集平均375毫升和660毫升的血浆。无论血浆置换的频率和次数如何，血小板计数、因子V和因子VIII活性、纤维蛋白原、纤溶酶原、α2-巨球蛋白、抗凝血酶III和凝血酶原时间均未观察到统计学上的显著变化。两组捐献者在进行七次血浆置换后，α1-抗胰蛋白酶浓度均已升高。高岭土-脑磷脂凝血时间随着采集血浆量的增加而逐渐缩短（p<0.05），凝血酶时间延长（p<0.05）。
