Ebert L, Pfitzer P
Virchows Arch B Cell Pathol. 1977 Aug 10;24(3):209-17. doi: 10.1007/BF02889280.
In 20 hearts the enlargement of muscle fibers and the increase in nuclear DNA is studied in the periphery of fresh and healed infarctions. The data of attack is verified by ECG records in most cases, five had passed undiagnosed. Selective cytophotometry is performed by measuring the largest nucleus in each of 50 fields of comparable density. Since significant differences in polyploidization exist between the control regions of hearts of similar weight primarily regions of the same heart are compared. No differences are observed in five hearts with infarctions about one week old. After five to six months the enlargement of the fibers is significaant (P less than 0.0005) while the increase in polyploidy is still slight (P less than 0.15). In all cases with scars one to nine years old the enlargement of fibers is significant (P less than 0.0005) while the increase in DNA is significant in most of them (5 X P less than 0.0005, 3 X P less than 0.005, 2 X P less than 0.01). In a case with two lesions, one posterior five (P less than 0.0005) and one anterior seven years old (P less than 0.0005), there is still slight increase in polyploidy with age (P less than 0.1). In the five undiagnosed cases only one has no significant increase in DNA. There is no correlation found between the enlargement of fibers and the increase in polyploidy in this limited number of cases.
在20颗心脏中，研究了新鲜梗死灶和愈合梗死灶周边的肌纤维增大及核DNA增加情况。多数情况下，发作数据通过心电图记录得以证实，有5例未被诊断出来。通过测量50个密度相当区域中每个区域最大的细胞核来进行选择性细胞光度测定。由于相似重量心脏的对照区域之间在多倍体化方面存在显著差异，所以主要比较同一心脏的区域。在约一周大的梗死灶的5颗心脏中未观察到差异。五到六个月后，纤维增大显著（P小于0.0005），而多倍体增加仍然轻微（P小于0.15）。在所有有一到九年陈旧瘢痕的病例中，纤维增大显著（P小于0.0005），而大多数病例中DNA增加显著（5例P小于0.0005，3例P小于0.005，2例P小于0.01）。在一个有两个病灶的病例中，一个病灶在后部，五年（P小于0.0005），另一个病灶在前部，七年（P小于0.0005），随着年龄增长多倍体仍有轻微增加（P小于0.1）。在5例未被诊断出的病例中，只有1例DNA没有显著增加。在这有限数量的病例中，未发现纤维增大与多倍体增加之间存在相关性。
