Vliegen H W, van der Laarse A, Cornelisse C J, Eulderink F
Department of Cardiology, Medical Faculty, University of Leiden, The Netherlands.
Eur Heart J. 1991 Apr;12(4):488-94. doi: 10.1093/oxfordjournals.eurheartj.a059928.
Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidization, multinucleation and relative volume fractions were studied. Regression analysis in relation to indexed heart weight yielded statistically significant correlation coefficients for myocyte volume: r = 0.69 (P less than 0.001), for degree of polyploidization: r = 0.77 (P less than 0.001), for number of nuclei per myocyte: r = 0.47 (P less than 0.01) and for volume fraction of myocytes: r = 0.32 (P less than 0.05). Approximate numbers of myocytes and connective tissue cells per left ventricle were calculated. Correlation coefficients related to indexed heart weight were r = 0.34 (P less than 0.05) for the number of myocytes and r = 0.76 (P less than 0.001) for the number of connective tissue cells. Based on regression analysis in relation to indexed heart weight, we calculated that a doubling of indexed heart weight was associated with an increase in mean myocyte volume by 65%, degree of polyploidization by 24%, multinucleation by 7%, number of myocytes by 20% and number of connective tissue cells by 141%. The volume percentage of myocytes decreased by 6% in favour of the connective tissue fraction. These changes in myocardial composition indicate that the term 'hypertrophy' inadequately describes the actual myocardial changes in response to pressure overload.
在22例正常心脏和21例肥厚性心脏（均为尸检获得）中，研究了与压力超负荷诱导的左心室肥厚相关的人类心肌形态学变化。样本取自左心室侧壁，位于心尖与心底之间的中点。研究了心肌细胞尺寸、多倍体化、多核化及相对体积分数。与心脏重量指数相关的回归分析得出，心肌细胞体积的相关系数具有统计学意义：r = 0.69（P＜0.001）；多倍体化程度：r = 0.77（P＜0.001）；每个心肌细胞核的数量：r = 0.47（P＜0.01）；心肌细胞体积分数：r = 0.32（P＜0.05）。计算了每个左心室中心肌细胞和结缔组织细胞的近似数量。与心脏重量指数相关的相关系数，心肌细胞数量为r = 0.34（P＜0.05），结缔组织细胞数量为r = 0.76（P＜0.001）。基于与心脏重量指数相关的回归分析，我们计算出心脏重量指数翻倍与平均心肌细胞体积增加65%、多倍体化程度增加24%、多核化增加7%、心肌细胞数量增加20%以及结缔组织细胞数量增加141%相关。心肌细胞的体积百分比下降了6%，有利于结缔组织部分。心肌组成的这些变化表明，“肥厚”一词不足以描述压力超负荷时实际的心肌变化。
