Moulopoulos L A, Varma D G, Dimopoulos M A, Leeds N E, Kim E E, Johnston D A, Alexanian R, Libshitz H I
Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Radiology. 1992 Dec;185(3):833-40. doi: 10.1148/radiology.185.3.1438772.
Spinal magnetic resonance (MR) imaging was performed in 29 patients with newly diagnosed, untreated multiple myeloma. Nineteen (66%) patients were asymptomatic. Sagittal pre- and postcontrast T1-weighted spin-echo images and gradient-recalled-echo images of the thoracic and lumbosacral spine were obtained. Marrow involvement was identified in 20 (69%) patients. There were three MR patterns: focal lesions in nine patients (31%), diffuse involvement in seven (24%), and an inhomogeneous pattern of tiny lesions on a background of normal marrow in four (14%). A statistically significant correlation between MR imaging patterns of marrow involvement and serum hemoglobin values (one-way, P = .0899; Kruskal-Wallis, P = .0620) and between MR imaging patterns and percentage of marrow plasmacytosis (Kruskal-Wallis, P = .0314) was noted, with patterns of diffuse and focal marrow involvement associated with more abnormal values. Spinal MR imaging in patients with early myeloma may reveal marrow involvement in both symptomatic and asymptomatic patients. Some correlation was found between MR imaging patterns and laboratory indexes of disease.
对29例新诊断的未经治疗的多发性骨髓瘤患者进行了脊柱磁共振（MR）成像检查。19例（66%）患者无症状。获取了胸椎和腰骶椎矢状位对比剂注射前后的T1加权自旋回波图像和梯度回波图像。20例（69%）患者发现有骨髓受累。有三种MR模式：9例患者（31%）为局灶性病变，7例（24%）为弥漫性受累，4例（14%）为正常骨髓背景下微小病变的不均匀模式。注意到骨髓受累的MR成像模式与血清血红蛋白值之间存在统计学显著相关性（单向，P = 0.0899；Kruskal-Wallis检验，P = 0.0620），以及MR成像模式与骨髓浆细胞增多百分比之间存在相关性（Kruskal-Wallis检验，P = 0.0314），弥漫性和局灶性骨髓受累模式与更异常的值相关。早期骨髓瘤患者的脊柱MR成像可能显示有症状和无症状患者均存在骨髓受累。在MR成像模式与疾病的实验室指标之间发现了一些相关性。
